abstract：:The presence of postural disturbance in patients with Parkinson's disease (PD) was assessed by the displacement of the centre of foot pressure (CFP) and by changes in the amplitude of the soleus H-reflex when patients maintained an upright standing posture, followed by a forward-leaning posture. Thirteen patients and ...

journal_title：Journal of the neurological sciences

authors： Hayashi R,Tokuda T,Tako K,Yanagisawa N

更新日期：1997-12-09 00:00:00

abstract：:A nitric oxide releasing compound, NOC-18, was injected intrathecally in order to determine the role of NO in spinal nociceptive mechanisms in rats. The nociceptive threshold was evaluated by the radiant heat tail-flick test. The effects of intrathecal injection of N-nitro-L-arginine methyl ester (L-NAME), an NO synth...

journal_title：Journal of the neurological sciences

authors： Inoue T,Mashimo T,Shibuta S,Yoshiya I

更新日期：1997-12-09 00:00:00

abstract：:We have monitored the cell surface phenotypic changes occurring in T, B and NK cells of chronic progressive multiple sclerosis (MS) patients after total lymphoid irradiation (TLI) plus low-dose prednisone (TLI-LDP) therapy in comparison to sham TLI-LDP. TLI-LDP resulted in a marked reduction in the relative and absolu...

journal_title：Journal of the neurological sciences

authors： Rohowsky-Kochan C,Molinaro D,Devereux C,Troiano R,Bansil S,Zito G,Wolansky L,Jotkowitz A,Denny T,Oleske J,Dowling P,Cook SD

更新日期：1997-11-25 00:00:00

abstract：:To systematically elucidate the gene expression of inflammatory and immune modulators following middle cerebral artery occlusion (MCAO) in the rat, we studied interleukin-10 (IL-10) along with tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and interleukin-2 (IL-2). Gene expression of these cyto...

journal_title：Journal of the neurological sciences

authors： Zhai QH,Futrell N,Chen FJ

更新日期：1997-11-25 00:00:00

abstract：:We have analyzed the serum from patients with refractory epilepsy for the presence of autoreactive antibodies to AMPA glutamate receptor subunits. The presence and the level of autoantibodies were assessed using immunoblot and ELISA with synthetic peptides specific for subregions of AMPA glutamate receptor subunits. P...

journal_title：Journal of the neurological sciences

authors： Dambinova SA,Izykenova GA,Burov SV,Grigorenko EV,Gromov SA

更新日期：1997-11-06 00:00:00

abstract：:Patients with diabetic amyotrophy may have an inflammatory vasculopathy and may obtain reversal of neurological deficits with immunosuppression. We present a patient with NIDDM, subacute onset of painful asymmetric polyradiculopathy, and unilateral enhancement of lumbar nerve roots on MRI. Clinical improvement and res...

journal_title：Journal of the neurological sciences

authors： O'Neill BJ,Flanders AE,Escandon SL,Tahmoush AJ

更新日期：1997-10-22 00:00:00

abstract：:The concentrations of sixteen amino acids have been measured in the serum and cerebrospinal fluid (CSF) of patients with Parkinson's disease and compared with those of control subjects. The levels of most amino acids were not different between the two groups, but the level of glutamate in CSF was decreased significant...

journal_title：Journal of the neurological sciences

authors： Mally J,Szalai G,Stone TW

更新日期：1997-10-22 00:00:00

abstract：:A case of central nervous system (CNS) leukemia with normal bone marrow, associated with a novel chromosomal abnormality, is described. A 58 year-old woman complained of hearing disturbance, severe headache and vomiting, and showed signs of meningeal irritation, as well as papilledema and bilateral dysacusis. Immature...

journal_title：Journal of the neurological sciences

authors： Hayashi T,Onodera J,Mochizuki H,Onodera H,Abe K,Itoyama Y

更新日期：1997-10-03 00:00:00

abstract：:Clinical remission in myasthenia gravis after thymectomy and immune suppressive treatment may be reflected by changes of immunoregulatory cytokines. Mononuclear cells from paired blood samples from fifteen patients with myasthenia gravis before and after thymectomy and immunosuppressive therapy were examined by in sit...

journal_title：Journal of the neurological sciences

authors： Weissert R,Melms A,Link H

更新日期：1997-10-03 00:00:00

abstract：:Riluzole is the first drug to be approved in the United States for the treatment of amyotrophic lateral sclerosis (ALS). During the first 8 months of the drug's availability by prescription, its use was discussed with 46 patients with probable or definite ALS as defined by the E1 Escorial criteria. Seventeen of the pa...

journal_title：Journal of the neurological sciences

authors： Rudnicki SA

更新日期：1997-10-01 00:00:00

abstract：:The recent history of clinical trials in ALS is marked by a great diversity in trial design. This has limited the comparability of the trial results, and has resulted in intense discussions about which parameters should or should not be evaluated when testing a new drug for ALS. This article discusses, without any cla...

journal_title：Journal of the neurological sciences

authors： Borasio GD

更新日期：1997-10-01 00:00:00

abstract：:McLeod syndrome is a rare X-linked disorder involving neurological defects and acanthocytosis. We examined the XK gene in three patients with neuroacanthocytosis, one of whom had cardiomyopathy, and his symptoms were very similar to those of McLeod syndrome. We found two new transversions (C to G at codon 204 and G to...

journal_title：Journal of the neurological sciences

authors： Shizuka M,Watanabe M,Aoki M,Ikeda Y,Mizushima K,Okamoto K,Itoyama Y,Abe K,Shoji M

更新日期：1997-09-10 00:00:00

abstract：:Nitric oxide (NO), a gaseous molecule synthesized in the arteriolar endothelium from the amino acid L-arginine (L-arg), has been identified as the previously described Endothelium-Derived Relaxing Factor (EDRF): nitroderivatives such as nitroglycerin are known to induce vasodilation via NO release. The aim of this stu...

journal_title：Journal of the neurological sciences

authors： Micieli G,Bosone D,Costa A,Cavallini A,Marcheselli S,Pompeo F,Nappi G

更新日期：1997-09-01 00:00:00

abstract：:A 90-year-old man with a longstanding bilateral essential tremor presented with right-sided weakness of sudden onset. The CT scan of the brain showed a hypodense area in the left side of the pons consistent with an infarction. The paralysis disappeared without recurrence of the tremor on the right, but the tremor pers...

journal_title：Journal of the neurological sciences

authors： Nagaratnam N,Kalasabail G

更新日期：1997-08-01 00:00:00

abstract：:The innervation of laryngeal muscle fibers was appraised in adult humans. Sixteen intrinsic laryngeal muscles were dissected during the autopsy of 4 adults (41-71 years old). Longitudinal serial frozen sections, 60 microm thick, of the whole muscles were double-stained for cholinesterase activity and axonal visualizat...

journal_title：Journal of the neurological sciences

authors： Périé S,St Guily JL,Callard P,Sebille A

更新日期：1997-07-01 00:00:00

abstract：:We studied neurite regeneration in MRL-lpr/lpr mice, a murine model of systemic lupus erythematosus, using a culture system to investigate the influences of immunological abnormalities on neurons. The regeneration of cultured dorsal root ganglion (DRG) neurons from MRL-lpr/lpr mice was delayed compared with control MR...

journal_title：Journal of the neurological sciences

authors： Hikawa N,Kiuchi Y,Maruyama T,Takenaka T

更新日期：1997-07-01 00:00:00

abstract：:We investigated whether the reduced intramembranous particles (IMP) in the muscle plasma membrane in mdx mice reflects a preferential depletion of a particular size of the IMP. The experiments were performed using the freeze-fracture method to analyze the frequency distribution of the size of IMP, the density of ortho...

journal_title：Journal of the neurological sciences

authors： Ito H,Yoshimura T,Tsujihata M,Nagataki S

更新日期：1997-05-29 00:00:00

abstract：:Pathologic laughter which usually occurs after bilateral or diffuse cerebral lesions was rarely reported in patients with unilateral stroke. I describe clinical and radiological findings of 13 patients presenting pathologic laughter due to unilateral stroke. Their laughter was excessive, unmotivated, uncontrollable an...

journal_title：Journal of the neurological sciences

authors： Kim JS

更新日期：1997-05-01 00:00:00

abstract：:We report on the case of a 70-year-old man with primary macroglobulinemia who showed cranial polyneuropathy and extensive radiculoneuropathy. His serum contained an IgM lambda monoclonal antibody which reacted with both a high molecular weight protein in grey matter and purified myelin basic protein (MBP) on immunoblo...

journal_title：Journal of the neurological sciences

authors： Kira J,Inuzuka T,Hozumi I,Wada H,Tanaka K,Gondo H,Sato S,Tsuji S,Kobayashi T

更新日期：1997-05-01 00:00:00

abstract：:A 53-year old woman developed slowly progressive dysarthria, mild enlargement of the tongue and dysphagia since 1 year ago. All neurological differential diagnoses that could have explained the bulbar symptoms were excluded. The swallowing sequence was pathologic and immunoglobulins were markedly reduced. A bone marro...

journal_title：Journal of the neurological sciences

authors： Finsterer J,Wogritsch C,Pokieser P,Vesely M,Ulrich W,Grisold W,Mamoli B

更新日期：1997-04-15 00:00:00

abstract：:In this study, we evaluated magnetization transfer ratio values in the brain white matter of siblings of multiple sclerosis (MS) patients and compared them to those obtained in sex- and age-matched normal controls. No statistically significant difference was found between the two groups for all the white matter areas ...

journal_title：Journal of the neurological sciences

authors： Filippi M,Campi A,Martino G,Colombo B,Comi G

更新日期：1997-04-15 00:00:00

abstract：:Hemorheologic changes from silent to acute and chronic cerebral infarction have seldom been reported. We evaluated hemorheologic profiles of the whole blood viscosity, plasma viscosity and fibrinogen level in stroke at-risk patients with silent cerebral infarction, patients with acute or chronic cerebral lacunar infar...

journal_title：Journal of the neurological sciences

authors： Tsuda Y,Satoh K,Kitadai M,Takahashi T

更新日期：1997-03-20 00:00:00

abstract：:We performed post-mortem examinations of three patients with progressive neurogenic amyotrophy of long duration. One patient had been clinically diagnosed as having sporadic amyotrophic lateral sclerosis (ALS) and two had been diagnosed with progressive spinal muscular atrophy (PSMA). The disease durations were 10, 17...

journal_title：Journal of the neurological sciences

authors： Iwanaga K,Hayashi S,Oyake M,Horikawa Y,Hayashi T,Wakabayashi M,Kondo H,Tsuji S,Takahashi H

更新日期：1997-03-10 00:00:00

abstract：:Starting after the age of 35 years this German man had a slowly progressive distal myopathy greater in the legs than in the arms. First he realized gait difficulties with reduced ankle dorsiflexion. Serum creatine kinase activity was normal. Muscle biopsy studies showed myopathic changes, rimmed vacuoles and the prese...

journal_title：Journal of the neurological sciences

authors： Sieb JP,VonOertzen J,Tolksdorf K,Dörfler P,Kappes-Horn K,Jerusalem F

更新日期：1997-02-27 00:00:00

abstract：:Subacute sclerosing panencephalitis is characterized by the insidious onset of diffuse cerebral dysfunction associated later with myoclonus and typical electroencephalographic changes. The disease progresses relentlessly to coma and death within 2 years. We report a case of acute onset and rapid course associated with...

journal_title：Journal of the neurological sciences

authors： Arora SC,Al-Tahan AR,Al-Zeer A,Al-Tahan F,Ozo CO,ur-Rahman N

更新日期：1997-02-27 00:00:00

abstract：:Despite the involvement of cerebellar ataxia in a large variety of conditions and its frequent association with other neurological symptoms, the quantification of the specific core of the cerebellar syndrome is possible and useful in Neurology. Recent studies have shown that cerebellar ataxia might be sensitive to var...

journal_title：Journal of the neurological sciences

authors： Trouillas P,Takayanagi T,Hallett M,Currier RD,Subramony SH,Wessel K,Bryer A,Diener HC,Massaquoi S,Gomez CM,Coutinho P,Ben Hamida M,Campanella G,Filla A,Schut L,Timann D,Honnorat J,Nighoghossian N,Manyam B

更新日期：1997-02-12 00:00:00

abstract：:An epidemic of subacute bilateral visual failure has affected large numbers of teenagers and young adult Africans in coastal Tanzania since 1988. Previous work had indicated that many patients had sensory symptoms, but the nature of the neurological involvement was uncertain. The primary objective of this study was to...

journal_title：Journal of the neurological sciences

authors： Plant GT,Mtanda AT,Arden GB,Johnson GJ

更新日期：1997-02-12 00:00:00

abstract：:The nosological relationship between Bickerstaff s brainstem encephalitis (BBE) and Guillain-Barre syndrome (GBS) has yet to be clarified. We report results of the autopsy of a patient for whom overlapping BBE and GBS was diagnosed clinically. This and similar cases support the original authors' hypothesis that BBE is...

journal_title：Journal of the neurological sciences

authors： Yuki N,Wakabayashi K,Yamada M,Seki K

更新日期：1997-01-01 00:00:00

abstract：:Positron emission tomography studies on the regional cerebral glucose metabolism (rCMRglc) and 18F-fluorodopa (18F-Dopa) uptake were performed in 3 patients with Machado-Joseph disease (MJD), a dominantly inherited degenerative disease in the cerebellum, brainstem and basal ganglia. The rCMRglc in MJD was found to be ...

journal_title：Journal of the neurological sciences

authors： Taniwaki T,Sakai T,Kobayashi T,Kuwabara Y,Otsuka M,Ichiya Y,Masuda K,Goto I

更新日期：1997-01-01 00:00:00

abstract：:An experimental autoimmune myositis (EAM) was produced by immunizing SJL/J mice with the myosin B (MB) fraction of the syngeneic muscle. Immunoblot analysis of the IgG of the EAM mice demonstrated antibodies against a variety of muscle proteins. The condition was then transferred to normal mice by both injecting immun...

journal_title：Journal of the neurological sciences

authors： Matsubara S,Okumura S

更新日期：1996-12-01 00:00:00

abstract：:The aims of this study were to test the theory that transduction of low-level electromagnetic fields (EMFs) is mediated like other stimuli, and to determine the false-negative rate of the method used to assess the occurrence of transduction (intra-subject comparison of stimulus and non-stimulus states (ICOS)). A light...

journal_title：Journal of the neurological sciences

authors： Marino AA,Bell GB,Chesson A

更新日期：1996-12-01 00:00:00

abstract：:Human leptomeningeal (arachnoid and pia mater) cells in culture have been demonstrated in replicated studies to express typical neuronal proteins such as neurofilament protein and neuron-specific enolase. In addition, they can express glial fibrillary acidic protein. The present study examines the possibility that neu...

journal_title：Journal of the neurological sciences

authors： Calingasan NY,Bernstein JJ,Blass JP

更新日期：1996-12-01 00:00:00

abstract：:A point mutation at codon 210 (GTT to ATT) of the prion protein gene on chromosome 20 was found in a 48-year-old CJD-affected woman of a Chinese family. This affected woman had an early onset and long-duration form of CJD. Serial magnetic resonance image (MRI) analysis of this woman showed severe brain atrophy, promin...

journal_title：Journal of the neurological sciences

authors： Shyu WC,Hsu YD,Kao MC,Tsao WL

更新日期：1996-11-01 00:00:00

abstract：:We investigated possible neurotoxic components in the cerebrospinal fluid (CSF) of patients with bacterial meningitis. On murine cerebellar neuronal cell cultures, CSF exerted a dose-dependent toxic effect, which was attenuated by the NMDA receptor antagonist MK-801. Glutamate concentrations in the CSF of patients wit...

journal_title：Journal of the neurological sciences

authors： Spranger M,Krempien S,Schwab S,Maiwald M,Bruno K,Hacke W

更新日期：1996-11-01 00:00:00

abstract：:Forty-three patients with Parkinson's disease (PD) and thirty-seven normal volunteers were subjected to clinical, neuropsychological, neurophysiological (P300 component of the event-related potentials ERP) and radiological (cranial computerized tomographic scanning CCT) evaluation. Intentional memory was more impaired...

journal_title：Journal of the neurological sciences

authors： Elwan OH,Baradah OH,Madkour O,Elwan H,Hassan AA,Elwan F,Mahfouz M,Ali A,Fahmy M

更新日期：1996-11-01 00:00:00

abstract：:Nitric oxide (NO) may be involved in myelin and oligodendrocyte injury associated with multiple sclerosis (MS), a demyelinating disease of unknown etiology. The cerebrospinal fluid (CSF) from MS patients may provide an important signal inducing a pathologic process within the central nervous system (CNS). To investiga...

journal_title：Journal of the neurological sciences

authors： Xiao BG,Zhang GX,Ma CG,Link H

更新日期：1996-10-01 00:00:00

abstract：:The diagnosis of epilepsy in the elderly can be difficult. We sought to determine whether video-EEG monitoring (VEEG) is useful in the diagnosis and management of elderly patients with epilepsy. We reviewed the medical records of 20 consecutive patients, over 60 years of age, selected from a total of 1423 patients ref...

journal_title：Journal of the neurological sciences

authors： Lancman ME,O'Donovan C,Dinner D,Coelho M,Lüders HO

更新日期：1996-10-01 00:00:00

abstract：:We investigated superoxide dismutase (SOD) activity in human cerebrospinal fluid (CSF) as an index of the aging process in the central nervous system (CNS). The subjects were 61 individuals aged 21-77 years, comprising 24 men and 37 women without organic disorders of the nervous system. SOD activity in CSF was measure...

journal_title：Journal of the neurological sciences

authors： Okabe T,Hamaguchi K,Inafuku T,Hara M

更新日期：1996-09-15 00:00:00

abstract：:We measured the CSF and plasma levels of glutamate, glutamine, aspartate (only in plasma), asparagine, glutamine, glycine and GABA in 31 patients with Parkinson's disease and in 45 matched controls. We used an ion-exchange chromatography method. When compared to controls, PD patients had similar CSF levels of glutamat...

journal_title：Journal of the neurological sciences

authors： Jiménez-Jiménez FJ,Molina JA,Vargas C,Gómez P,Navarro JA,Benito-León J,Ortí-Pareja M,Gasalla T,Cisneros E,Arenas J

更新日期：1996-09-15 00:00:00

abstract：:We report two patients with numb clumsy hands due to cervical spondylotic spinal cord compression. It is proposed that arterial insufficiency in the watershed area between the central and radial arterial systems of the cervical cord explains the sensory findings in the upper extremities with preservation of motor func...

journal_title：Journal of the neurological sciences

authors： Romano JG,Bradley WG,Green B

更新日期：1996-09-01 00:00:00